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Studies on obese diabetic (ob/ob) mice showed that GIP (Lys16PAL) and GIP (Lys37PAL) long-acting analogs for GIPR increased the insulin response to glucose and improved glucose tolerance [58]
However, larger trials have not consistently shown mortality benefit (Rank et al., Crit Care Med, 2000) [41]
This is where peptides are being explored as a supportive regenerative tool
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